It was the Portuguese who emphatically came out on top, scoring two penalties as Juventus triumphed 3-0 to claim top spot in Group G.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
Table-toppers Napoli, barely affected by injuries, have won five league matches in a row to extend their unbeaten run since the start of the season in both Serie A and the Champions League.
A summary of Saturday's action in La Liga, Serie A and Bundesliga.
Jamie Vardy scored his first goal in the Champions League to give Leicester City some hope of staying in Europe's elite competition despite a 2-1 loss to an utterly dominant Sevilla in Wednesday's last-16 first leg.
Champions Juventus continued their resurgence by beating Hellas Verona 3-0 at home for an eighth successive Serie A victory as Inter Milan remained top after winning 1-0 at Empoli.
Real Madrid edged past Sporting Lisbon 2-1, while Juventus came from behind to secure a 3-1 win at Sevilla and Borussia Dortmund crushed Legia Warsaw 8-4 to set a record for the most goals scored in a Champions League match.
A round-up of Saturday's action in Serie A, La Liga and Bundesliga.
News of all that's transpired on and off the football field
Real appointed former Spain manager Julen Lopetegui on Tuesday, but Allegri had been among the front-runners to take over from Zidane, who quit after winning a remarkable three successive Champions League trophies.
Real Madrid fought back from two goals down as Vinicius Jr grabbed a hat-trick in a thrilling 5-2 win over visitors Borussia Dortmund in the Champions League.
Juventus made light work of bitter rivals Inter Milan on Sunday, winning 3-1 to increase their Serie A lead to nine points after AS Roma were washed out and Napoli blundered to a 3-0 defeat at Atalanta.
Juventus midfielder Sami Khedira has been banned for two matches after being sent off in the derby against Torino for verbally abusing the referee.
Sevilla will bid for a record-extending seventh Europa League title when they face AS Roma in the final in Budapest on May 31, after Jose Mourinho's side drew 0-0 at Bayer Leverkusen to secure a 1-0 aggregate victory in their semi-final.
Lionel Messi-inspired Barcelona overwhelmed Manchester City as Ivan Rakitic's strike secured a 1-0 win.
'We have a team with much potential and we are showing that in the Champions League. It's not for nothing we have made it to the quarter-finals'
News of all that's transpired on and off the football field
Italian goalkeeper Gianluigi Buffon has retired from football, the 45-year-old announced on Wednesday, after 28 years in which he reached exceptional milestones for club and country.
Juventus scored twice in a minute as they came from behind to clinch a dramatic 3-2 win over Olympiakos after Andrea Pirlo had celebrated his 100th Champions League appearance by scoring from a characteristically effortless free kick on Tuesday.
News of all that's transpired on and off the football field
Paulo Dybala came off the bench to give unbeaten Serie A leaders Juventus a 1-0 win away to a brave Bologna side who had the better of the match and hit the post in stoppage time on Sunday.
Images from the Champions League matches played on Wednesday
Images from the football matches played on Tuesday.
Napoli kept their hopes of a first Serie A title since 1990 alive with an epic 4-2 win over 10-man Inter Milan after a Carlos Tevez hat-trick had put leaders Juventus six points clear with a 4-0 rout of Sassuolo on Sunday.
Napoli did not travel to Turin for the match on October 4, saying their local health authority (ASL) had told the players to stay at home after two members of their squad tested positive for COVID-19.
Inter Milan got a crucial 1-0 win at Juventus on Sunday
Manchester City suffered from deja vu as Luis Suarez's double gave Barcelona a 2-1 first leg lead in a Champions League last 16 tie at the Etihad although Lionel Messi's late penalty miss left the door ajar on Tuesday.
News of all that's transpired on and off the football field
Instead, Allegri said on Monday, he would throw on all his best attacking players in an attempt to outscore his opponents in the first leg at the Juventus stadium.
Juventus look set to wrap up their fourth successive Serie A title in the next seven days although the crowd violence which marred Sunday's 2-1 defeat at Torino could take the shine of their celebrations.
Says Real Madrid weaker without the Portuguese
News of all that's transpired on and off the football field.
Lionel Messi scored twice in the second half to help Barcelona to a 2-0 win over Arsenal in their UEFA Champions League round of 16, first leg match at the Emirates Stadium in London on Tuesday.
A summary of Tuesday's matches in the UEFA Champions League.
Lazio took another bite out of Juventus's lead at the top of Serie A when they beat Atalanta 2-0 on Sunday after Sergio Floccari appeared to use his hand before scoring the opening goal.
Juventus striker Carlos Tevez struck to give the Serie A champions a 1-0 win over AC Milan on Saturday, handing coach Massimiliano Allegri a winning return to San Siro where he was shown the door eight months ago.
Maurizio Sarri says he found Cristiano Ronaldo difficult to manage during his time in charge of Juventus, as he had to consider the 'personal interests' of the Portugal striker.
Juventus coach Antonio Conte is set to miss the whole of the Serie A season with the defending champions after losing his appeal against a 10-month ban over a match-fixing scandal on Wednesday.
In other European football action Real Madrid were left frustrated after a goalless draw against Athletic Bilbao in their La Liga match on Sunday.
IMAGES from the UEFA Champions League last 16 first leg matches played across Europe on Tuesday
